Hi Jason,

While it's not quite what you described, I'd recommend you check out the 
Secondary Structure Matching server at the EBI:

http://www.ebi.ac.uk/msd-srv/ssm/ssmstart.html

That will (hopefully!) give you previously deposited structures which share a 
similar fold to your query pdb file.

Hope this helps,

Isaac


> I am looking for software or a server to run the 3D-1D profile search  
> in reverse: that is I have a new structure (not in yet deposited in  
> PDB) and I want to see what sequences might fit well to this 3D  
> structure.
> Can someone point me in the right direction?
> 
> -jason

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