Hi Jason,
RosettaDesign server will do just that:
http://rosettadesign.med.unc.edu/
You can specify that certain residues remain unchanged (say active site),
that they fall into defined physico-chemical categories (polar, hyrophobic,
etc), or let the server change all residues into whatever is compatible
with your original structure.
If you want a stand-alone version of Rosetta:
http://depts.washington.edu/ventures/UW_Technology/Express_Licenses/Rosetta/
At 06:45 AM 4/2/2008, Jason Greenwald wrote:
I am looking for software or a server to run the 3D-1D profile search
in reverse: that is I have a new structure (not in yet deposited in
PDB) and I want to see what sequences might fit well to this 3D
structure.
Can someone point me in the right direction?
-jason
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