Dear Ed,
in the past we have successfully searched in an
electron density map (computed in the whole cell) with Molrep.
If you have a second crystal form and you can cut the density of the
monomer off, Phaser also gives very good results when
searching with that electron density - after that your maps can be
improved with dmmulti cross-crystal averaging.
Good luck!
Pietro
--
Pietro Roversi
EP Abraham Fellow in Biochemistry - Lincoln College - Oxford
Sir William Dunn School of Pathology, Oxford University
South Parks Road, Oxford OX1 3RE, England UK
Tel. 0044-1865-275385
