Dear Tassos, Bernhard and David,
If I may push this humourous response (obviously tainted with
crystallographic bias) a little further, I would say that my favourite
mnemonic for the acronym "NMR" is
N eeds
M ore
R esolution
Joking apart, of course, it is a devilishly clever method.
With best wishes,
Gerard.
--
On Fri, Nov 14, 2008 at 11:28:25AM +0100, Anastassis Perrakis wrote:
> Since I don't like attachments, I will first iterate the title of the
> attached publication:
>
> "Traditional Biomolecular Structure Determination by NMR Spectroscopy
> Allows for Major Errors "
>
> It immediately reminded me of an older one (ehm .. one author in common!),
> addressed at that time mostly to crystallographers:
>
> "Errors in protein structures." (Nature 1996)
>
> ... and I am afraid that the authors were right in both cases (they did not
> make many friends publishing these though)
>
> Crystallographers learned from that paper back then. And the participation
> of NMR spectroscopists on the 2006 paper
> implies they are also learning ;-)
>
> A.
>
> On Nov 14, 2008, at 6:34, Bernhard Rupp wrote:
>
>>> wondering what people think of this.
>>
>> Very funny.
>>
>> But no kidding, Richard Dickerson, the pioneer of DNA crystallography,
>> comes from your institution. For DNA, NMR has the benefit of readily
>> identifying intercalations in short oligomers etc w/o agony of
>> crystallizing.
>>
>> For others, pls see attached. As a physical principle, spectroscopic
>> methods do not deliver atomic resolution structures, but a set of
>> inferences that may or may no be compatible with a molecular model.
>>
>> BR
>> <Nabuurs_2006_PLOS_biomolecular_structure_NMR_errors.pdf>
--
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