Applications are invited for a postdoctoral position to work on the
structure determination of membrane transport proteins critical in
cardiovascular function. The transporters we study have been linked to
human disorders such as cardiomyopathy, ischemia-reperfusion injury,
and various cancers. Our aim is to understand the molecular regulation
of the transporters with the goal of rational design of novel
inhibitors and activators. We seek an enthusiastic candidate
experienced in macromolecular x-ray or electron crystallography.
Several projects are currently available, including 2D and 3D crystals
of membrane transport proteins and 3D crystals of soluble regulatory
proteins. Experience with membrane protein biochemistry would be an
asset. In addition, the successful candidate should be well-versed in
one or more of the following areas: molecular biology, protein
purification, crystallization, and membrane protein biochemistry.
This is an opportunity to join a lab experienced in the expression and
crystallization of membrane proteins [See Biophysical Journal (2006)
90:4213-23, JBC (2007) 282:9748-57, JBC (2008) 283:4145-54, and JBC
(2009) 284:13513-8]. Our department provides interaction with numerous
structural biologists. In addition, the University of Alberta Membrane
Protein Research Group provides a dedicated forum for membrane protein
research that includes 14 research laboratories
(http://www.mprg.med.ualberta.ca/index.php ).
The University of Alberta, located in Edmonton, Alberta (Canada), is
home to a large and interactive community of biomedical scientists
http://www.med.ualberta.ca/; support and facilities for structural
biology are excellent. A state-of-the-art facility is available for
electron microscopy at the National Institute for Nanotechnology,
University of Alberta
(http://nint-innt.nrc-cnrc.gc.ca/research/micro/index_e.html), and a
newly commissioned synchrotron facility is located a short drive away.
Edmonton, having a population of approximately 1 million, offers a
cosmopolitan environment with world class performing arts, sports,
culinary and recreational opportunities. In addition, the citys
proximity to the Rocky Mountains including the towns of Jasper and
Banff is an additional bonus.
Salary is commensurate with training and experience at competitive
rates. A comprehensive medical and dental benefit package is included
with salary. Postdoctoral fellowship awards are also available through
several competitive funding agencies, including the Canadian
Institutes for Health Research and Alberta Innovates Health
Solutions. The University of Alberta hires on the basis of merit. We
are committed to the principle of equity in employment. We welcome
diversity and encourage applications from all qualified women and men,
including persons with disabilities, members of visible minorities,
and Aboriginal persons. The records arising from this competition will
be managed in accordance with provisions of the Alberta Freedom of
Information and Protection of Privacy Act (FOIPP).
Please direct CV's or inquiries to Dr. Howard S. Young at the
following email address: hyo...@ualberta.ca.
Howard S. Young, PhD
Associate Professor & AHFMR Senior Scholar
Biochemistry, University of Alberta
Edmonton, Alberta T6G 2H7
(780)492-3931
National Institute for Nanotechnology,
National Research Council of Canada
Membrane Protein Research Group
(http://www.mprg.med.ualberta.ca/group-members.php)
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