Dear all, Please could you bring this advert to the attention of any potential candidates?
With industrialization, the production of chemicals and their introduction into the environment has increased massively. Some of these compounds act as endocrine disrupting chemicals (EDCs) that cause adverse effects in the endocrine system by interfering with hormone signaling. Epidemiological studies suggest a link between the increasing exposure to these chemicals and the development of the main diseases of the industrialized world including reproduction defects, hormone-related cancers, or metabolic disorders. We have launched a research program to elucidate the mechanisms by which EDCs bind to nuclear hormone receptors (NHRs) and in turn improve the predictability of the endocrine-disrupting potential of environmental contaminants. A 3-years postdoctoral research position is open (starting end 2010) at the Center for Structural Biochemistry (CBS) in Montpellier, France. The position requires the applicant to work on structural and biochemical characterization of NHRs including the peroxisome proliferator activated (PPAR), the estrogen (ER) or the androgen (AR) receptors in complex with EDCs. We are looking for highly motivated candidates with experience in protein purification, crystallization, X-ray data collection, structure determination and structural analysis. Applicants should send their CV and the names and contact information of at least three references via email to: William Bourguet Centre de Biochimie Structurale 29 rue de Navacelles 34090 Montpellier, France Tel : +(33) 4 67 41 77 02 Fax : +(33) 4 67 41 79 13 Email : bourg...@cbs.cnrs.fr CBS info : www.cbs.cnrs.fr Best regards, Albane le Maire
