----- Original Message ----- From: James Holton To: [email protected] Sent: Tuesday, October 26, 2010 6:31 PM Subject: Re: [ccp4bb] Against Method (R)
Yes, but what I think Frank is trying to point out is that the difference between Fobs and Fcalc in any given PDB entry is generally about 4-5 times larger than sigma(Fobs). In such situations, pretty much any standard statistical test will tell you that the model is "highly unlikely to be correct". Wow, so what is the answer to this? Is that figure "|Fcalc - Fobs| = 4-5x sigma" really true? How, then, do we believe structures? Are there really good structures where this is discrepancy is not there, to "stake our claim," so to speak?
