Hi, I have 2 rigid and fixed proteins and want to quickly judge whether there are some steric clashes. One quick way I am thinking is using CCP4 AREAIMOL to calculate the surfaces of each individual protein as well as the heterodimer, and check whether the sum of the two individual surfaces is larger then the dimer. I am wondering whether I can get some advices about this method.
I also know there must be some other tools to quickly do it since this is kinda a simple docking problem, and I appreciate if suggested some more direct methods. Finally, I am also wondering whether AREAIMOL considers the assymetric unit during calculation. Thanks! Hailiang
