[ccp4bb] help me after several refmac

[王瑞]

hello everyone:

    Excuse me, could anyone give me some suggestions? Afetr several cycles
of refmac, it give me such a result:
                                       Initial    Final
                    R factor    0.2540   0.2531
                       R free    0.3499   0.3500
     Rms BondLength    0.0151   0.0151
      Rms BondAngle    2.0266   2.0393
     Rms ChirVolume    0.1179   0.1188
 In fact, I have tried model building & continue refmac, but the R free is
still above 0.34. The resolution is  43.728 to  2.088Å and space group is C
2 2 21 . What I should to do?

Thanks