On the other hand, shooting a lower resolution crystal may get you the
conformation of the disordered domain.
Surprising at first thought, but was true in p97/VCP from the Brunger Lab.
F
On Dec 7, 2011, at 11:47 PM, atul kumar wrote:
> Dear all
>
> I have crytals which diffract up to 3.2 A at synchrotron, I am solving this
> by molecular replacement. I have built 70% of the model successfully,but the
> problem is it have a very poor density for some 30-40 residues at N terminal.
> I can't build anything in this region,this could be because of disordered
> structure or because of low resolution.what are the things which I can try to
> improve this?
>
> suggestion are requested!
>
> thanks
> regards'
> Atul Kumar
>
