On 02/07/2012 08:31 AM, Dialing Pretty wrote:
Dear All,

After we refine the structure of the protein to satisfactory with
satisfactory Rwork and Rfree, we pick water by phenix refine, and I find Rfree 
always increases slightly after the water picking refinment.

Do you have nay idea to solve this problem or any comment?

Cheers,

Dialing


Well - it shouldnt!

 Check if there is some problem..
Eleanor

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