Hi Giorgio, some XDS-related hints can be found at
http://strucbio.biologie.uni-konstanz.de/xdswiki/index.php/Small_molecules which I renamed to "Difficult datasets" since some of the suggestions also apply to those. What is lacking in that article is that you really should specify SENSOR_THICKNESS= and SILICON= . This is already taken care of in the Pilatus XDS.INP templates, but for CCD detectors this has to be specified manually; see hints in the script http://strucbio.biologie.uni-konstanz.de/xdswiki/index.php/Generate_XDS.INP HTH, Kay
