It may just be noise. Notice there there appears to be no electron density, 
only difference density.

Mark J van Raaij
Laboratorio M-4
Dpto de Estructura de Macromoleculas
Centro Nacional de Biotecnologia - CSIC
c/Darwin 3
E-28049 Madrid, Spain
tel. (+34) 91 585 4616
http://www.cnb.csic.es/~mjvanraaij



On 5 Nov 2012, at 01:38, yogesh khandokar wrote:

> Dear All
> 
> I am working on an enzyme which involved in fatty acid biosynthesis. We 
> solved the crystal structure of it. Biological unit of this enzyme is Hexamer 
> and showing extra electron density in the center of Hexamer. Wincoot software 
> doesn't recognize this extra electron density as water molecules/ substrate.  
> 
> My question is:Is there any way to find the molecules responsible for extra 
> electron density?
> 
> Picture is attached with email.
> 
> Thanks in advance for your comments.
> 
> Regards
> -- 
> Yogesh Khandokar
> PhD Student
> School of Biomedical Sciences
> Charles Sturt University
> Wagga Wagga, NSW,
> Australia
> http://www.csu.edu.au/faculty/science/biomed/
> 
> <Doc1.doc>

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