Hi all -
Anybody know
a) how hazardous is cacodylate?
b) does it really matter for crystallization screens?
It seems by far the most hazardous component of the standard screens;
this 2011 paper seems to think so (bizarrely, I can't access it from
Oxford):
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2818.1977.tb01136.x/abstract
and this is site says lethal dose is 0.5-5g/kg:
http://cameochemicals.noaa.gov/chemical/4468
meaning 2ml of a 0.1M solution contains 1/10th lethal dose...? (Someone
should check my maths...) [Coarse screens come mixed 2ml per condition.]
Has anybody done careful experiments that showed it really mattered for
a given crystal -- or even an entire screen?
So I'm inclined to toss it out entirely rather than make crystallization
screening a "hazardous activity". (We're being subjected to a safety
review.)
Thoughts welcome.
phx
