Re: [ccp4bb] Off-topic: NMR and crystallography

[C. Guttman]

Hi Theresa,
Per your question about determination of membrane proteins - solution NMR is 
quite capable of delivering structures of proteins in the presence of 
detergents, such as the KcsA channel (see 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242490/). You should note, though, 
that many membrane proteins are helical, and these proteins are  notoriously 
difficult to determine via NMR (see this article: 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862971/). Even so, if it won't 
crystallize, and you want it really bad, then go for it!
Chen