Anomalous signal analysis is quite early development in structural biology. There are couple of classical papers by Bijvoet in the first issues oaf Acta Crystallographica. Presently I am out of ability to find exact references :-/ Dr Felix Frolow Professor of Structural Biology and Biotechnology, Department of Molecular Microbiology and Biotechnology Tel Aviv University 69978, Israel
Acta Crystallographica F, co-editor e-mail: [email protected] Tel: ++972-3640-8723 Fax: ++972-3640-9407 Cellular: 0547 459 608 On May 13, 2014, at 10:38 , Tim Gruene <[email protected]> wrote: > Dear Javier, > > without the analysis of the anomalous signal you have a 50:50 chance to > get the correct configuration, and those times were too early for that. > The comment may have been added later and/or from using a different type > of experiment. > > Best, > Tim > > On 05/13/2014 02:21 AM, Javier Gonzalez wrote: >> Interestingly, that molecule has the opposite configuration. The actual >> model<http://upload.wikimedia.org/wikipedia/commons/6/6e/Molecular_model_of_Penicillin_by_Dorothy_Hodgkin_%289663803982%29.jpg>has >> a posting saying "(wrong absolute configuration)". >> I wonder what's the story behind it... >> >> >> >> >> On Mon, May 12, 2014 at 2:28 PM, Gregg Crichlow >> <[email protected]>wrote: >> >>> Actually, it was noticing penG that made me mouse over it myself. After >>> spending many years completing a thesis on beta-lactamases, I was very >>> surprised - and excited - to see that on something as main-stream as >>> Google. But then when I paid attention more closely, I saw that they even >>> have a good representation of the electron density in three orthogonal >>> planes surrounding the molecule! Dr. James Knox (my thesis advisor) just >>> informed me that the density maps are on exhibit at the British Museum of >>> Science. >>> I have heard so much about Dorothy Hodgkin from my thesis advisor, >>> that I became very familiar with her name and legacy, although I never had >>> met her. >>> >>> Gregg >>> >>> >>> On Mon, May 12, 2014 at 9:39 AM, Robert Sweet <[email protected]> wrote: >>> >>>> Check out google.com. They're announcing what would have been Dorothy >>>> Hodgkin's 104th b-day. I saw the molecule, and said to myself, "My >>>> goodness, that's penicillin G," and the mouseover announced the big day. >>>> >>>> She was a great scientist and a friend to thousands of us. >>>> >>>> Bob >>>> >>>> ========================================================================= >>>> Robert M. Sweet E-Dress: [email protected] >>>> Group Leader, PXRR: Macromolecular ^ (that's L >>>> Crystallography Research Resource at NSLS not 1) >>>> http://px.nsls.bnl.gov/ >>>> Photon Sciences and Biosciences Dept >>>> Office and mail, Bldg 745, a.k.a. LOB-5 >>>> Brookhaven Nat'l Lab. Phones: >>>> Upton, NY 11973 631 344 3401 (Office) >>>> U.S.A. 631 344 2741 (Facsimile) >>>> ========================================================================= >>>> >>> >>> >> >> > > -- > Dr Tim Gruene > Institut fuer anorganische Chemie > Tammannstr. 4 > D-37077 Goettingen > > GPG Key ID = A46BEE1A >
