Dear Felix, I now, of course. The molecule on the picture look like consisting of rather light atoms, and I would be very impressed if the instrumentation and software at that time allowed the reliable detection of the hand from that particular molecule.
I don't assume Dorothy Hodgkin made a mistake leading to that note but rather realised of what was available to her and made the best of it (which was clearly very outstanding). But of course I may be wrong and I am happy to learn. Best, Tim On 05/13/2014 10:12 AM, Felix Frolow wrote: > Anomalous signal analysis is quite early development in structural biology. > There are couple of classical papers by Bijvoet in > the first issues oaf Acta Crystallographica. Presently I am out of ability > to find exact references :-/ > Dr Felix Frolow > Professor of Structural Biology and Biotechnology, Department of Molecular > Microbiology and Biotechnology > Tel Aviv University 69978, Israel > > Acta Crystallographica F, co-editor > > e-mail: [email protected] > Tel: ++972-3640-8723 > Fax: ++972-3640-9407 > Cellular: 0547 459 608 > > On May 13, 2014, at 10:38 , Tim Gruene <[email protected]> wrote: > >> Dear Javier, >> >> without the analysis of the anomalous signal you have a 50:50 chance to >> get the correct configuration, and those times were too early for that. >> The comment may have been added later and/or from using a different type >> of experiment. >> >> Best, >> Tim >> >> On 05/13/2014 02:21 AM, Javier Gonzalez wrote: >>> Interestingly, that molecule has the opposite configuration. The actual >>> model<http://upload.wikimedia.org/wikipedia/commons/6/6e/Molecular_model_of_Penicillin_by_Dorothy_Hodgkin_%289663803982%29.jpg>has >>> a posting saying "(wrong absolute configuration)". >>> I wonder what's the story behind it... >>> >>> >>> >>> >>> On Mon, May 12, 2014 at 2:28 PM, Gregg Crichlow >>> <[email protected]>wrote: >>> >>>> Actually, it was noticing penG that made me mouse over it myself. After >>>> spending many years completing a thesis on beta-lactamases, I was very >>>> surprised - and excited - to see that on something as main-stream as >>>> Google. But then when I paid attention more closely, I saw that they even >>>> have a good representation of the electron density in three orthogonal >>>> planes surrounding the molecule! Dr. James Knox (my thesis advisor) just >>>> informed me that the density maps are on exhibit at the British Museum of >>>> Science. >>>> I have heard so much about Dorothy Hodgkin from my thesis advisor, >>>> that I became very familiar with her name and legacy, although I never had >>>> met her. >>>> >>>> Gregg >>>> >>>> >>>> On Mon, May 12, 2014 at 9:39 AM, Robert Sweet <[email protected]> wrote: >>>> >>>>> Check out google.com. They're announcing what would have been Dorothy >>>>> Hodgkin's 104th b-day. I saw the molecule, and said to myself, "My >>>>> goodness, that's penicillin G," and the mouseover announced the big day. >>>>> >>>>> She was a great scientist and a friend to thousands of us. >>>>> >>>>> Bob >>>>> >>>>> ========================================================================= >>>>> Robert M. Sweet E-Dress: [email protected] >>>>> Group Leader, PXRR: Macromolecular ^ (that's L >>>>> Crystallography Research Resource at NSLS not 1) >>>>> http://px.nsls.bnl.gov/ >>>>> Photon Sciences and Biosciences Dept >>>>> Office and mail, Bldg 745, a.k.a. LOB-5 >>>>> Brookhaven Nat'l Lab. Phones: >>>>> Upton, NY 11973 631 344 3401 (Office) >>>>> U.S.A. 631 344 2741 (Facsimile) >>>>> ========================================================================= >>>>> >>>> >>>> >>> >>> >> >> -- >> Dr Tim Gruene >> Institut fuer anorganische Chemie >> Tammannstr. 4 >> D-37077 Goettingen >> >> GPG Key ID = A46BEE1A >> > > -- Dr Tim Gruene Institut fuer anorganische Chemie Tammannstr. 4 D-37077 Goettingen GPG Key ID = A46BEE1A
signature.asc
Description: OpenPGP digital signature
