I2 and C2 are different settings of the same group. The official IUCr 
convention is to use the one which gives the beta angle closer to 90 degrees. 
As far as I know all programs should now be able to use the I2 setting, but if 
it worries you, you can reindex to C2

Phil

On 21 May 2014, at 17:54, Roberto Battistutta <[email protected]> 
wrote:

> Dear All,
> a question about C2 and I2 space groups.
> Processing a dataset, XDS output says C2, with dimensions 122.8, 56,9 81,5 
> and beta 125.1°.
> Aimless reindexes to I2 with 81.6, 56.9, 101.1 and 96.2°.
> Phenix (refine) returns a warning "NOTE: non-standard setting used: I 1 2 1".
> In the PDB there are indeed several examples of I2 choices.
> 
> The two space groups are equivalent as indicated in the International Tables 
> (all with number 5), but why different programs use different conventions? Is 
> there any rationale? By the way, the volumes of the two unit cells are very 
> similar.
> 
> Thanks,
> Roberto.
> 
> 
> Roberto Battistutta
> Associate Professor
> Department of Chemistry
> University of Padua
> via Marzolo 1, 35131 Padova - ITALY
> tel. +39.049.827.5262
> fax. +39.049.827.5829
> [email protected]
> www.chimica.unipd.it/roberto.battistutta/
> VIMM (Venetian Institute of Molecular Medicine)
> via Orus 2, 35129 Padova - ITALY
> tel. +39.049.7923.236
> fax +39.049.7923.250
> www.vimm.it

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