We are seeking highly motivated postdoctoral fellows to join the Biosynthetic Enzymes Laboratory at the University of British Columbia in Vancouver, Canada (https://www.chem.ubc.ca/katherine-ryan). We are a dynamic group of researchers working at the interface of chemistry and biology. Our goal is to elucidate the pathways that lead to natural product molecules. Applicants are sought primarily in two areas: (1) X-ray crystallography. Top candidates will have strong experience in protein expression and purification, crystallization trials, data collection, and structure determination, and can independently determine the structures of enzymes in complex with ligands. Projects will be centered on structural investigations of biosynthetic enzymes, to complement ongoing biochemical and mechanistic studies. (2) Microbial genetics. Top candidates will have demonstrated expertise in microbial genetics (bacterial or fungal systems) and the ability to rapidly carry out protocols in molecular biology. A strong interest (or, ideally, prior exposure) to basic chemical techniques (purification, HPLC, MS, NMR, etc.) is highly desired. Projects will be centered on elucidating and engineering pathways to complex natural product molecules. Top candidates with a strong interest in biosynthesis (with other backgrounds) will also be given consideration. Please send your CV to Katherine Ryan at ksr...@chem.ubc.ca. Our laboratory is located centrally in the vibrant UBC campus, with easy access to the ocean, mountains, and downtown. Vancouver is routinely ranked as the most livable city in the world.
