Monica, I struggled with this a lot too. I had some success with low molecular weight PEG (100-400) as a solvent, its well worth a try. -bob
On Wed, Oct 15, 2014 at 9:13 AM, Monica Mittal <monica.mitta...@gmail.com> wrote: > Dear All > > Can anyone give suggestions for handling the solubility problem of > highly hydrophobic compounds, during co-crystallization or inhibition > assays? > The ligands I am using are almost insoluble in aquous medium. In DMSO > or 95% Ethanol, the solubility is higher. > Besides crystallization, this solubility is also a hindrance for > in-vitro or in-vivo assays requiring higher conc. of ligand. > > Thanks in advance ! > Monica >
