It looks as if you have a and b about the same length. In that case indexing of 
the patterns may randomly switch h and k. The CCP4 program Pointless (in ccp4i 
Data reduction -> Symmetry, Scale, Merge (aimless) or Find or Match Laue 
group). Give your 1st dataset as the reference.

Phil

On 30 Dec 2014, at 06:04, Thyageshwar Chandran <[email protected]> 
wrote:

> Dear all,
> I have a query regarding the interchanging of axis !
> 
> My native crystals are orthorhombic (P21212), and i did soaking with 
> different ligands, after solving the structures when i compared the unit 
> cell, the orientation of the molecule was different in three cases (90 degree 
> rotation), hence had to interchange a and b for them (changed it in SF h=k, 
> k=h) , my query is thought the conditions were similar in all the cases, how 
> come only in the said cases the change occurred! i wonder if i am doing the 
> correct thing by interchanging the axis....please advice and let me know if 
> you had come across similar such cases....
> 
> i had attached the figure for clarity ( i am talking about the last three 
> cases)
> 
> many thanks
> 
> regards,
> thii
> 
> On 28 December 2014 at 12:18, <Thii> <[email protected]> wrote:
> Dear all,
> I have a query regarding the interchanging of axis !
> 
> My native crystals are orthorhombic (P21212), and i did soaking with 
> different ligands, after solving the structures when i compared the unit 
> cell, the orientation of the molecule was different in three cases (90 degree 
> rotation), hence had to interchange a and b for them (changed it in SF h=k, 
> k=h) , my query is thought the conditions were similar in all the cases, how 
> come only in the said cases the change occurred! i wonder if i am doing the 
> correct thing by interchanging the axis....please advice and let me know if 
> you had come across similar such cases....
> 
> 
> many thanks
> 
> regards,
> thii
> 
> 
> 
> 
> -- 
> "When we long for life without difficulties, remind us that oaks grow strong 
> in contrary winds and diamonds are made under pressure."
> <combined-all-picture.png>

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