Dear CCP4 users, Recently, I got some datasets with weak anomalous Br signal. I tried to merge them according to Q. Liu et al Science 336, p1033 (2012). I am using the script multiscale@SSRL. The merged dataset has WEAKER anomalous signals.
Liu et al used SCALA for scaling and merging while multiscale@SSRL using AIMLESS. Should this cause such a difference? The SCALA@SSRL has a limitation on the number of frames it can process. So I cannot directly check if this caused the difference. Any suggestions? Thanks! Charles -- *************************************************** Charles Chen Research Associate University of Pittsburgh School of Medicine Department of Anesthesiology ******************************************************
