POSTDOCTORAL POSITION - Molecular machines dealing with proteotoxic stresss A 3-year postdoctoral position is available in the laboratory of Dr. Tim Clausen at the Research Institute of Molecular Pathology (IMP) in Vienna to study molecular machines removing toxic protein aggregates. Our laboratory is interested in (i) protein quality control and stress response pathways, (ii) the role of specific protein modifications therein, and (iii) the networking of chaperones carrying out the assembly of multi-protein complexes. We recently discovered protease-chaperone machineries that are of fundamental importance for intercellular signaling (Cell, 2013, 155, 647) and for forming myosin filaments (Cell, 2013, 152, 183), and identified a novel post-translational protein modification (phospho-arginine; Science, 2009, 324, 1323) coordinating the bacterial stress response. Regarding the latter point, we developed mass spectrometric procedures to monitor the occurrence and turnover of pArg protein modification on the proteomic scale (Mol Cell Proteomics, 2014, 13, 537). For further information of the group, please have a look at http://clausen.imp.ac.at . By applying a novel methodology specialized for dynamic protein complexes, we will analyze the structure and function of molecular machines mediating the degradation and disaggregation of damaged proteins. To this end, we will use the proteasome and the Hsp104 disaggregase as model systems. Preliminary data from our lab point to novel regulatory and structural features that are critical for the various housecleaning activities and for taming the otherwise dangerous protein shredders. To pursue a further, in-depth mechanistic analysis, we are looking for a highly motivated postdoc candidate. The position will provide a unique and multi-disciplinary exposure to modern Structural Biology. Located at the IMP (http://imp.ac.at), a leading international research institute in one of the world's best cities, our lab has access to cutting-edge service facilities and benefits from the excellent research community at the Vienna Biocenter Campus (http://www.viennabiocenter.org). The ideal candidate will have a doctoral degree and a published expertise in Biochemistry, Structural Biology or related fields. We particularly welcome applications from candidates interested in working at the interface of protein crystallography, electron microscopy and mass spectrometry. Please send a letter of intent, your CV, and names of 3 referees to Tim Clausen ([email protected]) .
