Dear Luke, sorry for the late reply, but e.g. autoSHARP would do the MR-XYZ combination (it doesn't really matter what XYZ is: SAD, SIRAS, SIR, MIR, MIRAS, MAD). See [1] for combining the two approaches.
Cheers Clemens [1] https://www.globalphasing.com/sharp/wiki/index.cgi?RunAutoSharp https://www.globalphasing.com/sharp/wiki/index.cgi?ExamplesAutoSharp https://www.globalphasing.com/sharp/wiki/index.cgi?ExamplesAutoProcAutoSharp On Tue, Jul 23, 2019 at 04:44:44PM +0800, Luke Smithers wrote: > Hi all, > > I have collected native data and data on a bromide derivative of one of my > crystals, but have struggled to get a second derivative. I went through the > SIR pipeline as the anomalous signal from the Br was weak and have > generated some not-so-great phases. I have also attempted MR with the > closest match in the PDB (which is only 22% sequence identity) and got some > more not-so-great phases. I have found plenty of programs that will combine > SAD/MR phases, is there anything that will do SIR/MR? I understand it's > likely I will need more and better data and ideally a second derivative but > thought it was worth putting it out there to see if there is something like > this. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
