*
*
*Mail-in protein-to-structure services to support structural biology
research related to COVID-19 at the EMBL Grenoble HTX Lab and the joint
EMBL-ESRF MX beamlines.*
*
*
The ESRF-EMBL Joint Structural Biology Group (JSBG) invite COVID-19
related proposals that can benefit from the seamless integration of the
EMBL High throughput Crystallization Facility (HTX Lab) with the highly
automated JSBG MX beamlines at the ESRF. The pipeline starts with
mail-in samples and integrates crystallization screening, crystal
optimization, ligand soaking if required and eventually fragment
screening with libraries of up to 1200 fragments. Crystals obtained will
be automatically harvested and passed to the ESRF for automated X-ray
data collection, with real-time access to experimental results and
parameters. This pipeline is uniquely suited to support structural
biology projects in conditions of confinement and restricted access to
labs. The HTX lab is already accepting crystallization projects on
COVID-19 related research and three MX beamlines (MASSIF-1 (ID30A-1),
ID30B and ID23-2) will become operational from mid-May.
Users wishing to benefit from this combined access for COVID-19
research, should send an e-mail to jsbg-covid...@embl.fr indicating
interest, whereupon a short application form will be sent for completion.
Jose A. Marquez
Head of the Crystallization Facility
EMBL Grenoble
marq...@embl.fr
Gordon Leonard
Head of the MX group
ESRF
leon...@esrf.fr
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