Dear Rafal,
The difference map you show in your attachment has an echo of the main 
structure sort of look. So, I suggest you examine your diffraction images 
specifically looking out for a supercell of weak intensity spots, not picked up 
by the autoindexing, between the main lattice of intensities, which provided 
your current unit cell.
Best wishes,
John
Emeritus Professor John R Helliwell DSc




> On 29 Jul 2020, at 13:42, Rafal Dolot <[email protected]> wrote:
> 
> Dear CCP4 users,
> 
> I'm working on the another nucleic acid duplex structure. After several 
> stages of rebuilding and refinement I observed something like a "shadow" of 
> the second duplex position. Have you any ideas to explain this phenomena? 
> Should I place the second molecule with occupancy completed to the first one? 
> Or maybe is it a kind of disorder in crystal lattice? Data were collected to 
> 1.02A using synchrotron radiation (processed with XDS), but I have another 
> datasets collected to lower resolution (from Zn-SAD) with visible similar 
> effects. Refinement was done using Refmac (R/Rfree 21.5/24.0). Data not 
> appeared to be twinned, but Xtriage detected pseudo-translational symmetry.
> 
> Thank you for any advices.
> 
> Rafal
> 
> |----------------------------------------------|
> |Rafal Dolot, Ph.D.                            |
> |                                              |
> |Polish Academy of Sciences                    |
> |Centre of Molecular and Macromolecular Studies|
> |Department of Bioorganic Chemistry            |
> |Macromolecular Crystallography Team           |
> |Sienkiewicza 112                              |
> |90-363 Lodz, Poland                           |
> |Phone: +48(42)6803215                         |
> |Cell:  +48 502897781                          |
> |----------------------------------------------|
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