Eventually computational methods (like AlphaFold) should provide reliable information on the spectrum of metastable conformational substates that a protein can adopt, i.e. its dynamics. This information will be valuable to answer the question of a protein's function, and also of its crystallization - and if it is only: difficult!
Best, Hans -----Original Message----- From: CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK> On Behalf Of Bryan Lepore Sent: Freitag, 11. Dezember 2020 15:03 To: CCP4BB@JISCMAIL.AC.UK Subject: Re: [ccp4bb] External: Re: [ccp4bb] AlphaFold: more thinking and less pipetting (?) > On Dec 11, 2020, at 07:42, Phil Evans <p...@mrc-lmb.cam.ac.uk> wrote: > > But I’ve always thought the more interesting question is “this is the > structure, what does it do?” It sounds compelling though, that methods of the sort implemented in the CASP work are perfectly poised to make progress on the question: “how might this protein crystallize?” -Bryan W. Lepore ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/ ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
