I'm afraid that the "Kent" variant is also mutating and is likely to pick up
some of the more challenging mutations. There is already a version circulating
with the E484 mutation that has a clear impact on the vaccine ("Bristol"
variant), and another picked up in Scotland that has several changes similar to
the SA variant.
The UK is sequencing a _lot_ and picking up a lot of changes. Probably the
message is that if a virus new to humans circulates enough, it's going to
mutate to find its optimal niche.
Nic
-----Original Message-----
From: CCP4 bulletin board <[email protected]> On Behalf Of Ethan A Merritt
Sent: 17 February 2021 20:57
To: [email protected]
Subject: Re: [ccp4bb] Contagious, Self-Distributing "Vaccines?"
It may be here already.
For a value of B that includes "no worse than the starting point", the
so-called "UK variant" currently spreading in the US meets your criteria. Some
projections show it displacing other potentially more dangerous variants while
not not degrading the impact of vaccination and other public health measures.
Are you starting a conspiracy theory that it was the result of a clandestine
good samaritan molecular biologist?
Ethan
On Wednesday, 17 February 2021 12:39:21 PST Jacob Keller wrote:
> I was under the impression that A,B,C are not strongly or
> intrinsically coupled, for one, since there are so many varieties of
> viruses with so much range of infectiousness and clinical severity. False
> impression?
>
> B + C = vaccine
>
> A + B + C = immunosysadmin pandemic updater virus. Patient 0 honors
> given for each (yearly?) edition to curry political favor.
>
> JPK
>
>
> On Wed, Feb 17, 2021 at 3:03 PM Tim Gruene <[email protected]> wrote:
>
> > Hi Jacob,
> >
> > how do you think this should be possible? In order to infect others,
> > the virus particle needs to proliferate (that's the only thing it
> > does). It profilerates by hijacking the machinery of one cell of
> > your body and turn it into a virus factory. Your body does not like
> > this abuse and kills the cell, and also tries to kill the virus particles.
> > The virus does not make you sick, it only captures one cell. The
> > reaction of your body to kick out the virus, and the cell that does
> > not do it's job anymore, make you sick. A and B are mutually
> > exclusive. B + C is named vaccine.
> >
> > Best,
> > Tim
> >
> >
> > On Wed, 17 Feb 2021 12:33:09 -0500 Jacob Keller
> > <[email protected]> wrote:
> >
> > > It would seem to me that it should be possible to generate
> > > versions of the Covid virus that would:
> > >
> > > A. be extremely contagious and yet B. be clinically benign, and C.
> > > confer immunity to the original covid virus.
> > >
> > > If, then, this virus could be released, with appropriate "kill switch"
> > > safeguards built in, would this not solve the world's pandemic
> > > problems? Is there any reason, practically, why this approach
> > > would not be feasible?
> > >
> > > Maybe we don't really know enough to manipulate A, B, C yet?
> > >
> > > Or maybe it's too scary for primetime...nightmare bio-warfare
> > > apocalypse?
> > >
> > > Has this sort of thing been done, or does it have a name?
> > >
> > > Jacob
> >
> >
> >
> > --
> > --
> > Tim Gruene
> > Head of the Centre for X-ray Structure Analysis Faculty of Chemistry
> > University of Vienna
> >
> > Phone: +43-1-4277-70202
> >
> > GPG Key ID = A46BEE1A
> >
>
>
>
--
Ethan A Merritt
Biomolecular Structure Center, K-428 Health Sciences Bldg
MS 357742, University of Washington, Seattle 98195-7742
########################################################################
To unsubscribe from the CCP4BB list, click the following link:
https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.jiscmail.ac.uk%2Fcgi-bin%2FWA-JISC.exe%3FSUBED1%3DCCP4BB%26A%3D1&data=04%7C01%7CN.J.Harmer%40exeter.ac.uk%7C4b309b2facb84ecfbf4208d8d387103b%7C912a5d77fb984eeeaf321334d8f04a53%7C0%7C0%7C637491924339146877%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=%2BE%2BP%2BFmT3ssBHfhdafYUaDE0yb0Z2vTmlRTTG7HD48w%3D&reserved=0
This message was issued to members of
https://eur03.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.jiscmail.ac.uk%2FCCP4BB&data=04%7C01%7CN.J.Harmer%40exeter.ac.uk%7C4b309b2facb84ecfbf4208d8d387103b%7C912a5d77fb984eeeaf321334d8f04a53%7C0%7C0%7C637491924339146877%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=zlAw%2F95oetjwm9N8y0u9vUju4qdqf7iy22aTeOrrlOY%3D&reserved=0,
a mailing list hosted by
https://eur03.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.jiscmail.ac.uk%2F&data=04%7C01%7CN.J.Harmer%40exeter.ac.uk%7C4b309b2facb84ecfbf4208d8d387103b%7C912a5d77fb984eeeaf321334d8f04a53%7C0%7C0%7C637491924339146877%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=dosEZcaSlYwjZCR4Rf1X6vgyioWwQV0cNt3SSzhV7vk%3D&reserved=0,
terms & conditions are available at
https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.jiscmail.ac.uk%2Fpolicyandsecurity%2F&data=04%7C01%7CN.J.Harmer%40exeter.ac.uk%7C4b309b2facb84ecfbf4208d8d387103b%7C912a5d77fb984eeeaf321334d8f04a53%7C0%7C0%7C637491924339146877%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=o1bzjODWffUq7FKilhP47R6YjtzNCWs%2BTXrM3mC%2BDfk%3D&reserved=0
########################################################################
To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list
hosted by www.jiscmail.ac.uk, terms & conditions are available at
https://www.jiscmail.ac.uk/policyandsecurity/
