STRUCTURAL BIOLOGY AND FUNCTION OF NEUROTRANSMITTER TRANSPORT A post-doctoral position is available in the laboratory of Dr. Robert M. Stroud at the mission bay campus of the University of California San Francisco (UCSF). (https://msg.ucsf.edu/people/robert-stroud-ma-phd <https://msg.ucsf.edu/people/robert-stroud-ma-phd>). Research in our group is focused on the structure and mechanisms of transmembrane processes, and particularly in this position on the mechanisms and regulation of transporters that package neurotransmitters into synaptic vesicles in the nervous system and the brain. These provide for the ‘quantal release’ in neuronal signaling. Structures are determined by cryo-electron microscopy, cryo-electron tomography, X-ray diffraction as inroads to defining the structural basis of function. This also involves expression and purification of membrane proteins, or complexes, use of detergents, and nanodiscs, and assays of transport in vesicles and in cells. Example see (https://www.ncbi.nlm.nih.gov/pubmed/32439795 <https://www.ncbi.nlm.nih.gov/pubmed/32439795>). Experience in cryo-EM and any of these areas is an advantage. First rate facilities are available in a highly collaborative environment. NRSA postdoctoral stipend levels+benefits. If interested please send a brief cover letter, CV and contact information for three persons who might provide references to Robert Stroud ([email protected] <mailto:[email protected]>) Deadline July31st
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