UC San Francisco – Postdoctoral Position Opening Ion Channel Structural and Chemical Biology
MINOR LAB UCSF - Cardiovascular Research Institute, Departments of Biochemistry and Biophysics, & Cellular and Molecular Pharmacology A Postdoctoral position is available immediately for highly motivated individuals with a strong interest in studies of ion channels in the lab of Prof. Dan Minor at the University of California, San Francisco (UCSF). The Minor Lab merges structural, biochemical, chemical biology, genetic, and electrophysiological methods to dissect mechanisms of complex protein machines involved in electrical signaling. Projects focus on biochemical, electrophysiological, and cell based approaches to studying ion channel function, the development of new chemical biology tools to manipulate channel activity, studies of ion channel lipid interactions, and on determining the structures of ion channel complexes by both crystallographic and single particle cryo-electron microscopy (cryo-EM) approaches. The fellow will benefit from both the outstanding lab environment and the highly collaborative UCSF community. As part of the UCSF Macromolecular Structure Group, the lab uses an extensive set of crystallographic and cryo-EM resources, including: two R-axis IV systems, regular access to synchrotron beamline 8.3.1 at the nearby Advanced Light Source (ALS) in Berkeley, and on campus state-of-the-art Talos Arctica and Titan Krios cryo-EMs using the latest generation of K2 Summit direct electron detectors. Ongoing projects focus on mechanisms of voltage-gated, thermosensitive, and mechanosensitive channels and efforts develop new agents to control and image ion channels involved in pain represented by: Arrigoni, C., Rohaim, A., Shaya, D., Findeisen ,F., Stein, R.A. Nurva, S.R., Mishra, S., Mchaourab, H.S., and Minor, D.L., Jr., ‘Unfolding of a temperature-sensitive domain controls voltage-gated channel activation’ Cell 164 922-936 (2016) Lolicato, M., Arrigoni, C., Mori, T., Sekioka, Y., Bryant, C., Clark, K.A., Minor, D.L., Jr. ’K2P2.1(TREK-1):activator complexes reveal a cryptic selectivity filter binding site’ Nature 547 364-368 (2017) Lolicato, M., Natale, A., Abderemane-Ali, F., Crottès, D. Capponi, S., Duman, R., Wagner, A., Rosenberg, J.M., Grabe. M., and Minor, D.L., Jr. ’K2P2.1 channel C‑type gating involves asymmetric selectivity filter order-disorder transitions’ Science Advances 6 eabc9174 (2020) More information is available at the lab website http://www.cvri.ucsf.edu/~dminor/ <http://www.cvri.ucsf.edu/~dminor/> Candidates should have (or expect) an Ph.D. or M.D. and should have experience in protein biochemistry, cell biology, electrophysiology, or structure determination by crystallographic or cryo-electronmicroscopy methods. TO APPLY: Interested individuals should send a current CV to Prof. Daniel Minor at [email protected] <mailto:[email protected]> Dan Minor, Ph.D. Professor Cardiovascular Research Institute Departments of Biochemistry & Biophysics, and Cellular & Molecular Pharmacology California Institute for Quantitative Biomedical Research Kavli Institute for Fundamental Neuroscience University of California, San Francisco FEDEX/UPS address: Cardiovascular Research Institute Box 3122 University of California San Francisco 555 Mission Bay Blvd. South. Rm 452Z San Francisco, CA 94158-9001 Email: [email protected] <mailto:[email protected]> Phone: 415-514-2551 Fax: 415-476-8173 Web: http://www.cvri.ucsf.edu/~dminor <http://www.cvri.ucsf.edu/~dminor> Twitter:http://twitter.com/ElectrosomeUCSF <http://twitter.com/ElectrosomeUCSF> _______________________________________________ 3dem mailing list [email protected] <mailto:[email protected]> https://mail.ncmir.ucsd.edu/mailman/listinfo/3dem <https://mail.ncmir.ucsd.edu/mailman/listinfo/3dem> Dan Minor, Ph.D. Professor Cardiovascular Research Institute Departments of Biochemistry & Biophysics, and Cellular & Molecular Pharmacology California Institute for Quantitative Biomedical Research Kavli Institute for Fundamental Neuroscience University of California, San Francisco FEDEX/UPS address: Cardiovascular Research Institute Box 3122 University of California San Francisco 555 Mission Bay Blvd. South. Rm 452Z San Francisco, CA 94158-9001 Email: [email protected] Phone: 415-514-2551 Fax: 415-476-8173 Web: http://www.cvri.ucsf.edu/~dminor Twitter:http://twitter.com/ElectrosomeUCSF ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
smime.p7s
Description: S/MIME cryptographic signature
