Dear Colleagues, There is an immediate opening for a Senior Scientist position at Merck & Co., Inc in our West Point, Pennsylvania, USA structural biology group.
Please use the link below to learn more about the position and to apply. All applicants will need to apply through our jobs site (use link below). https://jobs.merck.com/us/en/job/R185174/Structural-Chemistry-Senior-Scientist Best regards, Dan -------- Daniel J. Klein, Ph.D. Director, Computational & Structural Chemistry Merck Research Laboratories Merck & Co., Inc. West Point, PA, USA This position within our company's Computational and Structural Chemistry (CSC) Department will support drug discovery through the use of atomic resolution macromolecular X-ray crystallography and single particle CryoEM to determine the structures of therapeutically important drug targets to accelerate the discovery of new medicines. The successful candidate will join our growing structural biology team at our West Point, Pennsylvania site, and will be responsible for all aspects of the experimental process from sample preparation and data collection through data processing, structure elucidation, and effective communication of structural analyses with key stakeholders. Additionally, the candidate will work proactively with colleagues in Discovery Chemistry, Protein Sciences, and the global CSC network, and will also be expected to identify and manage internal and external scientific partnerships as necessary. Productive and collaborative interactions with other members of our global, cross-functional department are required. Inclusive and collaborative use of internal expertise and resources will be essential to success. The successful candidate is expected to foster and contribute to a diverse workforce where colleagues and partners feel comfortable bringing their unique perspectives to work. The position requires active interaction with the external scientific community to continually improve scientific understanding, including presentations at external meetings. There is an expectation for periodic travel to other locations. Minimum required education: Ph.D. in structural biology, biochemistry, or related field. Required Experience and Skills: * Demonstrated experience in a broad range of activities for X-ray crystallography, including screening and crystal optimization, data collection, and structure elucidation of small molecule protein complexes or multi-subunit protein complexes. * Experience with automation for x-ray crystallography (Mosquito, NT8, etc.). * Excellent written and oral communication skills that enhance team-based progress is required. Application of those skills both within and outside the department to ensure the maximum understanding of program status for therapeutic area project teams and management is required. * Demonstrated organizational skills, including ability to manage multiple projects and subsequent prioritization. * Ability to work effectively and flexibly within timelines. * Ability to prepare peer-reviewed publications. Preferred Experience and Skills: * Experience with sample preparation and structure elucidation by single particle CryoEM * Co-crystallization, seeding, ligand soaking, crystal harvesting & freezing. Proficiency in data collection, data processing, and structure elucidation by X-ray crystallography and/or cryo-EM. * Experience with fragment-based lead identification, including primary X-ray fragment screening. * Experience with structure-based antigen design for vaccine discovery. * In-depth knowledge of current biophysical and functional characterization methods (e.g. SPR, BioNMR, thermal shift, ligand-binding, and calorimetric assays) to guide construct design and optimization. * Experience using computational tools for protein engineering and design. * Experience with scientific programming (e.g. Python) and interest in the application of computational tools to answer structural biology questions. This e-mail message, together with any attachments, contains information of Merck & Co., Inc. (126 East Lincoln Ave., P.O. Box 2000, Rahway, NJ USA 07065) and/or its affiliates, that may be confidential, proprietary copyrighted and/or legally privileged. (Direct contact information for affiliates is available at - Contact us - MSD <https://www.msd.com/contact-us/>.) It is intended solely for the use of the individual or entity named on this message. If you are not the intended recipient, and have received this message in error, please notify us immediately by reply e-mail and then delete it from your system. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
