Hi Kristoffer

OK I see that the MTZ file you used going into EDSTATS (hkl_ed.mtz) does
have an FOM column so I'm still puzzled why it didn't work the first time.
Ignoring errors is only a good idea if you know what the errors are and are
confident they're not going to affect the results!  I would need this file
to work out what exactly happened.

Cheers

-- Ian


On Wed, 12 Oct 2022 at 12:03, Kristoffer Lundgren <
[email protected]> wrote:

> Hi Ian,
>
>
>
> Thanks for looking into this!
>
>
>
> The -noerror flag seems to allow edstats.pl to run to completion for me
> as well.
>
>
>
> The maps for edstats.pl are generated by using phenix.maps (version
> 1.20.1-4487) with the attached maps.params file (maybe this file is
> configured wrong?). Before this step I have run a quantum refinement of the
> model as outlined in
> https://onlinelibrary.wiley.com/iucr/doi/10.1107/S205979831900175X which
> is the reason for the slightly changed file names.
>
>
>
> EDSTATS is then executed through a small script:
>
>
>
> cad hklin1 bindividual1_fixed_refine_001_fmodel.mtz hklin2
> bindividual1_fixed_refine_001_map_coeffs.mtz hklout hkl_ed.mtz<<EOF
>
> LABIN FILE 1 E1=FOBS E2=SIGFOBS E3=FCALC E4=PHIFCALC E5=FOM E6=R_FREE_FLAGS
>
> LABOUT FILE 1 E1=FOBS E2=SIGFOBS E3=FC E4=PHIC E5=FOM E6=FREE
>
> LABIN FILE 2 ALL
>
> EOF
>
> edstats.pl -xyzin bindividual1_fixed_refine_001.pdb -hklin hkl_ed.mtz
> -flabel FOBS -atomsf atomsf_neutron
>
>
>
> Best regards
>
> Kristoffer
>
>
>
>
>
> *From: *Ian Tickle <[email protected]>
> *Date: *Tuesday, 11 October 2022 at 19:33
> *To: *Kristoffer Lundgren <[email protected]>
> *Cc: *"[email protected]" <[email protected]>
> *Subject: *Re: [ccp4bb] Error while running EDSTATS
>
>
>
>
>
> Hi Kristoffer
>
>
>
> The deposited structure factor file is missing an FOM column which is
> needed for MTZFIX to do its job of checking the veracity of the FWT and
> DELFWT columns.  The message I get with CCP4 7.1 is different, in fact it's
> exactly what I expect:
>
>
>
>  mtzfix:  ERROR: Labels not found - maybe non-standard labels used?
>
>
>
> i.e. telling you that it's missing required column(s), not the "corrupt
> output file" message which suggests something got mangled.
>
>
>
> Can you tell me _exactly_ what you typed on the command line from the
> point after you downloaded and unzipped the data files?
>
>
>
> What happens if you skip the MTZFIX step by adding the '-noerror' flag to
> the command line?  This ran to completion for me, though I haven't checked
> the results to see if they make sense.
>
>
>
> If that doesn't help you will have to recompute the structure factors from
> the model using 'NCYC 0' in Refmac.  That will output all the required
> columns so you should be able to proceed normally.
>
>
>
> The error message "ERROR in radius calculation: max iterations" indicates
> a more serious problem, such as an inability to handle the density profile
> for Mn.  I'm puzzled how it got that far since the MTZFIX failure should
> have terminated the run before it got to that point.
>
>
>
> See if any of that helps.
>
>
>
> Cheers
>
>
>
> -- Ian
>
>
>
>
>
> On Tue, 11 Oct 2022 at 17:09, Kristoffer Lundgren <
> [email protected]> wrote:
>
> Dear all,
>
>
>
> I am trying to run EDSTATS on a neutron structure containing a manganese
> ion (https://www.rcsb.org/structure/7KKW), but either I am doing
> something wrong or something is broken. When using EDSTATS supplied with
> CCP4 8.0 I end up with the error message:
>
>
>
> mtzfix:  WARNING: Output file is corrupt so deleted.
>
>
>
> ERROR in mtzfix: stopping.
>
>
>
>
>
> Using EDSTATS supplied with CCP4 7.0, the error message instead becomes:
>
>
>
> ERROR in radius calculation: max iterations.
>
>
>
> ERROR in RADINT:   2
>
>
>
>
>
> Oddly enough, when changing MN to FE in the model, EDSTATS in CCP4 7.0
> works fine. EDSTATS in CCP4 8.0 with FE however again gives me the error
> message:
>
>
>
> mtzfix:  WARNING: Output file is corrupt so deleted.
>
>
>
> ERROR in mtzfix: stopping.
>
>
>
>
>
> Any help or advice would be greatly appreciated!
>
>
>
> Kind regards
>
> Kristoffer Lundgren
>
>
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