Hi Bashir,

It does look like you have translational pseudo-symmetry. If the translation 
vector happens to be body-centering, it could affect your intensity statistics 
so that the R-values would never go down as half of your reflections follow the 
distribution for centric reflections. I had this a long time ago; you might 
want to check https://doi.org/10.1107/S0907444906031519.

HTH,
Esko

Sent from my iPhone

On 27 Jun 2023, at 19:03, Muhammad Bashir Khan <[email protected]> wrote:


Hello All;

I have x-rays data of about 100 kDa protein at 3.3A. It gives MR statistics as 
LLG 150 and TFZ 7 but when I switched off the tNCS I got an LLG around 2500 and 
TFZ 45, but the R and Rfree are stuck at 39 and 43. The space group is 4. Any 
suggestion in this regard will be highly appreciated. Patterson's analysis is 
attached.

Thank you all

Bashir

--
------------------------------------------------------
Muhammad Bashir Khan, Ph.D.
Research Associate
Department of Biochemistry
Medical Science Bldg.
Lab 3-27
University of Alberta
Edmonton AB, T6G 2H7

Phone: 780-492-4577-
e-mail: [email protected]<mailto:[email protected]>

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