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Postdoctoral positions in integrative structural biology study of signaling complexes The Page Laboratory at the University of Connecticut Health Center has an immediate opening for up to two postdoctoral candidates to study eukaryotic signaling enzymes, with a focus on the function of phosphatases that form large signaling complexes and phosphatase drug/inhibitor development (recent publications include Nature [https://www.nature.com/articles/s41586-023-06870-3], Nature communications [https://www.nature.com/articles/s41467-023-37372-5]). All studies combine cryo-EM, NMR and/or X-ray crystallography with biochemical and cellular experiments, allowing postdocs to augment their training in those techniques that are new. Applicants with strong backgrounds in biochemical techniques, and especially eukaryotic protein expression and protein crystallization or cryoEM, are encouraged to apply. The Page laboratory is housed in a newly renovated ~250,000 sq. ft. research laboratory in Farmington, CT. The laboratories are open-lab-space facilities and allow close interaction with the adjunct structural biology and molecular/cell biology groups at UConn Health. The Page laboratory is equipped with all necessary infrastructure to produce (E. coli, mammalian, insect), purify and analyze protein and protein complexes (ITC, SPR etc.) and crystallization robotics for crystal production (Art Robbins Gryphon LCP nano-liter crystallization robot; Art Robbins CrysCam) as well as all needed equipment for cryo-EM sample preparation and data evaluation. UCHC facilities include a Bruker Venture D8 system (IμS Diamond source) with a Photon III M14 detector and cold stream is available for crystal screening and data collection for in-house data collection, synchrotron access at NSLS-II, SSRL, Diamond and high-field NMRs (Bruker Avance Neo 600 MHz and 800 MHz NMR spectrometers). Cryo-EM instrument includes a TFS Vitrobot IV and a TFS Tundra/Falcon C) that allows for rapid screening of auto-grid/clipped samples of sample conditions. Access to Krios instruments for data collection is readily available. UCHC has a welcoming, collaborative and vibrant environment for structural, biochemical and translational research. Farmington, CT, is located in New England between Boston (90 min.) and New York City (90 min). Laboratory alumni are successful, including alums that have their own academic faculty positions, are directors/chief scientists in pharma and startups, gone into public policy, among others. Starting date, salary and project details are very competitive and negotiable. Please e-mail a Cover Letter and CV to Rebecca Page (rp...@uchc.edu) Rebecca Page, PhD Professor UConn Health | Cell Biology (L5080) 263 Farmington Avenue | Farmington, CT 06030 rp...@uchc.edu Page laboratory website<https://sites.google.com/view/pagelaboratory/home> ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
