Hi Harry
I always think about big regulatory complexes when it comes to this. 2G28, a
pyruvate dehydrogenase, or 8FWP, a septin that regulates the cell cycle in
yeast, might answer the question you are looking for.
Best wishes
______________________________________________________
Rafael Marques da Silva
PhD Student – Structural Biology
University of Leicester
Mestre em Física Biomolecular
Universidade de São Paulo
Bacharel em Ciências Biológicas
Universidade Federal de São Carlos
phone: +44 07861 273773
"A sorte acompanha uma mente bem treinada"
________________________________________________
________________________________
De: CCP4 bulletin board <[email protected]> em nome de Nichols, Charlie
<[email protected]>
Enviado: sexta-feira, 20 de dezembro de 2024 11:17
Para: [email protected] <[email protected]>
Assunto: Re: [ccp4bb] enzyme or other protein with multiple cofactors
Hi Harry,
PDB 1QLB is 2.33A and has protoporphyrin, FAD and Fe-S clusters bound…
https://www.rcsb.org/structure/1QLB
respiratory complex II-like fumarate reductase from Wolinella succinogenes
Cheers, Charlie.
From: CCP4 bulletin board <[email protected]> On Behalf Of Harry Powell
Sent: Friday, December 20, 2024 10:38 AM
To: [email protected]
Subject: [ccp4bb] enzyme or other protein with multiple cofactors
WARNING: This message was sent by an external party. Report suspicious messages
via the “Report Phishing” button in Outlook.
Hi folks
I’m familiar with enzymes that have a single co-factor (for example haem in
myoglobin [or in the individual chains in haemoglobins] or FAD in
flavoproteins), but was wondering if there are examples of single-chain
proteins that have multiple cofactors (or even multiple chain proteins that
have multiple cofactors bound to a single chain)?
I’m not bothered (at the moment) about proteins that have cofactors bound to
different chains.
I thought this would be a good place to ask…
Harry
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