Wow. I was right about one thing - this _is_ a good place to ask. Many thanks for the flood of responses - that will keep me busy for a while - I’ll get back to you with what I think are the most useful ones for my purposes (so many, many apologies to those people who have taken the time to respond but came up with suggestions that didn’t "hit the spot" for some reason!).
Just for the record, I’m not interested in any co-factors like water or “isolated” metal ions (so not part of a bigger assembly - I’m interested in things like haem, for example, but not things like hexaaquacobalt). So anything that has (say) FAD and ADP bound by the same chain would pique my interest - especially if both are listed in the corresponding UniProt KB entry (just because a PDB entry has more than one ligand bound, they may not both really be cofactors…). If UniProt KB tells me that there’s only one cofactor (or worse, none), then I will rapidly move on (unless someone can provide a solid justification as to why UniProt is wrong and they’re right…). Enjoy a solstice-oriented break! best wishes Harry > On 20 Dec 2024, at 10:37, Harry Powell > <[email protected]> wrote: > > Hi folks > > I’m familiar with enzymes that have a single co-factor (for example haem in > myoglobin [or in the individual chains in haemoglobins] or FAD in > flavoproteins), but was wondering if there are examples of single-chain > proteins that have multiple cofactors (or even multiple chain proteins that > have multiple cofactors bound to a single chain)? > > I’m not bothered (at the moment) about proteins that have cofactors bound to > different chains. > > I thought this would be a good place to ask… > > Harry > ######################################################################## > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > > This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing > list hosted by www.jiscmail.ac.uk, terms & conditions are available at > https://www.jiscmail.ac.uk/policyandsecurity/ ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
