Sorry Tim, I very much doubt that Marin's analysis does not apply equally to x-ray diffraction. Apart from imaging being just equivalent to 1 unit cell, crystallography increasingly uses photon counting detectors which, according to Marin, will also have a direct connection to the measurement problem. Investigating this could be like falling down a rabbit hole. You might now have to spend sleepless nights worry about the fundamental basis of what you have been doing since you started your career.
If you want to avoid this, one can just accept that the measurement problem is similar to trying to determine which slit a particle goes through in a 2 slit experiment. This could involve choosing one of the many interpretations of quantum mechanics. Or you could otherwise accept it is a central mystery and leave it at that. Of course, Marin might have solved this central mystery! Good luck Colin -----Original Message----- From: CCP4 bulletin board <[email protected]> On Behalf Of Tim Gruene Sent: 06 October 2025 14:46 To: [email protected] Subject: Re: [ccp4bb] Single Electron Counting, The Measurement Problem, Symmetric Sampling I am so happy I do diffraction, not microscopy Tim On Sat, 4 Oct 2025 19:13:10 -0300 Marin van Heel <[email protected]> wrote: > Dear All, > > Electron counting cameras in Cryo-EM have an unexpected direct > connection to the Measurement Problem in Quantum Mechanics. In fact, > the measurement problem already existed in Classical Newtonian Physics > due to its Deterministic Mathematical Axioms and is not specifically > tied to Quantum Mechanics. The Measurement Problem also existed in > Shannon’s sampling theorem. All measurements, and not only those in > Electron Microscopy must adhere to symmetric-sampling rules. > Check the link to a series of papers: > > https://www.linkedin.com/feed/update/urn:li:activity:73795154194240225 > 28/ > > Sorry, I know it is tough stuff… > > Marin > > ###################################################################### > ## > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > > This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a > mailing list hosted by www.jiscmail.ac.uk, terms & conditions are > available at https://www.jiscmail.ac.uk/policyandsecurity/ -- -- Tim Gruene Head of the Core Facility Crystal Structure Analysis Faculty of Chemistry University of Vienna Phone: +43-1-4277-70202 https://ccsa.univie.ac.at GPG Key ID = A46BEE1A ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/ This e-mail and any attachments may contain confidential, copyright and or privileged material, and are for the use of the intended addressee only. If you are not the intended addressee or an authorised recipient of the addressee please notify us of receipt by returning the e-mail and do not use, copy, retain, distribute or disclose the information in or attached to the e-mail. Any opinions expressed within this e-mail are those of the individual and not necessarily of Diamond Light Source Ltd. Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments are free from viruses and we cannot accept liability for any damage which you may sustain as a result of software viruses which may be transmitted in or with the message. Diamond Light Source Limited (company no. 4375679). Registered in England and Wales with its registered office at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
