Hi Armando,

Tools such as fpocket (https://github.com/Discngine/fpocket) can do this
with relative ease. There is a web version:
https://durrantlab.pitt.edu/fpocketweb/

All the best,

Natalie

*Dr. Natalie J. Tatum (she/her)*

Senior Research Associate, Newcastle Drug Discovery

Lead Academic in Structural Computational Chemistry, CRH-TI
Cancer Research Horizons Newcastle
Translational and Clinical Research Institute, Newcastle University


On Fri, 12 Dec 2025 at 07:53, Armando Albert <
[email protected]> wrote:

> Dear all,
> How can I measure the volume of a cavity? What if it is connected to the
> solvent?
> Armando
>
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