Hi,
 
I haven't used it myself, but just got a promotional email about these: 
https://swissci.com/product/cerocon-0-5ml-ultrafiltration-device/ They claim it 
goes down to 10uL?
 
Best,
Andrea





Pondělí, Leden 19, 2026 15:15 CET, "Mark J. van Raaij" 
<[email protected]> napsal:

 
Dear All, 
the smallest centrifugal protein concentrators I know take sample volumes of 
0.5 ml, like these: https://www.sigmaaldrich.com/ES/es/product/mm/ufc5010 (but 
other brands are also available). In theory you should be able to get to less 
than 40. In practice it is difficult. A problem is that, with a total protein 
amount of below 0.5 mg, a significant amount of it will stick to the plastic of 
the tubes and the filter, so it just becomes impossible to get very small 
volumes. I was wondering if there are other solutions available? Or efforts to 
miniaturise this? (apart from lyophilisation, which is not suitable for many 
proteins).

 Best wishes, Mark

 Mark van Raaij
Dpto de Estructura de Macromoleculas, lab B5B
Centro Nacional de Biotecnologia - CSIC
calle Darwin 3
E-28049 Madrid, Spain
tel. +34 91 585 4616 (internal 432092)

 

 

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