Just throwing it out there, but what if its an aperiodic crystal?

https://pmc.ncbi.nlm.nih.gov/articles/PMC4005373/

I ran into something where I had an odd unit cell (something like 40,40,330) in 
P212121 and terrible Rwork/Rfree, could see some satellite spots, but I 
couldn't do too much with the data and decided to move on. Was a small globular 
protein, normally well behaved, so nothing like your helical bundle.

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