I was also thinking is there static disorder / aperiodicity? An other example: 
https://www.sciencedirect.com/science/article/pii/S0022283698923853?via%3Dihub

Look at the P1 case could be helpful.

Best,
Rachelle

___________________________________________________________________
 Rachelle Gaudet, Ph.D.
 Professor and Chair
 Department of Molecular and Cellular Biology
 Co-Director of Graduate Studies, Biophysics
 Harvard University
 52 Oxford Street, Northwest Labs room 311.13
 Cambridge, MA 02138
 Voice: (617) 495-5616    e-mail: [email protected]
 https://projects.iq.harvard.edu/gaudetlab/home
___________________________________________________________________

-----Original Message-----
From: CCP4 bulletin board <[email protected]> On Behalf Of Henry Man
Sent: Friday, February 6, 2026 9:58 AM
To: [email protected]
Subject: Re: [ccp4bb] Crystal pathology diagnosis please

Just throwing it out there, but what if its an aperiodic crystal?

https://pmc.ncbi.nlm.nih.gov/articles/PMC4005373/

I ran into something where I had an odd unit cell (something like 40,40,330) in 
P212121 and terrible Rwork/Rfree, could see some satellite spots, but I 
couldn't do too much with the data and decided to move on. Was a small globular 
protein, normally well behaved, so nothing like your helical bundle.

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