If you use ChimeraX, you can run KVFinder directly from the menu "Tools / 
Structure Analysis / Find Cavities" and this will get you an interactive 
visualization. Documentation: 
https://www.cgl.ucsf.edu/chimerax/docs/user/tools/findcavities.html


Cheers,


Guillaume

________________________________
From: CCP4 bulletin board <[email protected]> on behalf of Xavier 
Brazzolotto <[email protected]>
Sent: Friday, July 24, 2026 8:28:56 PM
To: [email protected]
Subject: Re: [ccp4bb] Protein cavity volume calculation

The web server KVFinder does the job I want and is quite user-friendly

Thank you all for your advices

Xavier

Le 24 juil. 2026 à 19:59, Jeffrey Bonanno <[email protected]> a 
écrit :

We have used fpocket

Jeffrey B. Bonanno, Ph.D.
Department of Biochemistry
Albert Einstein College of Medicine
1300 Morris Park Avenue
Bronx, NY 10461
off. 718-430-2452 fax. 718-430-8565
email [email protected]<mailto:[email protected]>

From: CCP4 bulletin board <[email protected]<mailto:[email protected]>> 
On Behalf Of Xavier Brazzolotto
Sent: Friday, July 24, 2026 1:57 PM
To: [email protected]<mailto:[email protected]>
Subject: [ccp4bb] Protein cavity volume calculation

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Sorry for the bit off-list question,

I would like to calculate a cavity volume using CASTp 3.0, but the server 
(http://sts.bioe.uic.edu/castp/calculation.html) doesn’t seem to respond.

Is the calculation service down permanently, or is there any other alternative?

Xavier

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