Iron affects everyone it's not a case of if it effects you as an individual,
too much iron will cause you problems if you take to much especially to the
liver.




-----Original Message-----
From: Dana [mailto:[EMAIL PROTECTED] 
Sent: 18 January 2005 01:20
To: CF-Community
Subject: restless legs causation

I found what I was thinking of and it was iron not calcium. Past
experience makes me add that too much iron is toxic, so if you think
this applies to you please see a doctor instead of self-medicating.
But here is the link. I know nothing else about this disorder. Don't
have it, con't kow anyone that has it, just happen to have noticed
this:

http://www.mayoclinic.org/news2004-rst/2547.html

Mayo Clinic in Rochester

Tuesday, December 28, 2004

Mayo Clinic Finds Restless Legs Syndrome in Children Linked to Family
History, Iron Deficiency
Researchers note that "growing pains" may in fact be restless legs syndrome

   Additional Resources 
   
Video Clips and Sound Bites: Restless Legs Syndrome in Children  
 
Treatment of Sleep Disorders in Children  
 
Other Web Resource: Becoming a Patient  
 
 
 
 
Journalists:
For more information, contact:
Lisa Lucier
507-284-5005 (days)
507-284-2511 (evenings)
[EMAIL PROTECTED] 
 
  
 
ROCHESTER, Minn. -- A new Mayo Clinic study has for the first time
established rates of restless legs syndrome in children, finding that
almost 6 percent of children seen in Mayo's sleep clinic have the
disease. The study, published in this month's issue of Annals of
Neurology, also notes that the most common risk factors for the
disease in kids are family history of restless legs syndrome and iron
deficiency.

"Restless legs syndrome is underdiagnosed in kids," says Suresh
Kotagal, M.D., chair of Mayo Clinic pediatric neurology and a sleep
specialist. "If you look at children with difficulty falling asleep,
you'll see a fair number have restless legs. Thus far, there have been
sporadic case reports, but nobody has studied a larger group of
children, looking at children with insomnia complaints as a whole to
see how many had restless legs syndrome."

Dr. Kotagal and his colleague Michael Silber, M.B.Ch.B., Mayo Clinic
neurologist and sleep specialist, indicate that restless legs syndrome
may account for some of the age-old notion of "growing pains."

"It's been known for decades that children have 'growing pains,'" says
Dr. Kotagal. "Studies by other investigators have now shown that
growing pains in some children may actually be restless legs
syndrome."

Dr. Kotagal says that while infrequent "growing pains" may be
immaterial, parents and children should be alert for a habitual
pattern of discomfort in the limbs around bedtime.

"Occasional growing pains are nothing to worry about, but growing
pains every night may be restless legs syndrome," he says. "It's like
the fact that somebody might snore one or two days a month, but if it
happens every night, it may be something that needs medical
attention."

The study examined the records of 538 children who had been seen in
the pediatric sleep disorders program at Mayo Clinic between Jan. 2000
and March 2004. New, rigidly defined diagnostic criteria established
by a consensus conference of the National Institutes of Health and the
International Restless Legs Syndrome Foundation in 2003 allowed the
Mayo Clinic researchers to classify their 32 patients as having
probable restless legs in nine cases and definite restless legs
syndrome in 23 cases. Those in the probable restless legs syndrome
group were more likely to be younger. The most common symptoms were
trouble getting to sleep or staying asleep, which affected 87.5
percent. One commonality in the restless legs syndrome patients was a
low iron level in the blood (as measured by serum ferritin) seen in 83
percent of the patients, the explanation for which is unknown,
according to Dr. Kotagal.

"With regard to the iron deficiency, we don't know if it's the diet or
a genetic predisposition to low iron levels," says Dr. Kotagal. Drs.
Kotagal and Silber also found family history of restless legs syndrome
in 23 out of 32 patients identified to have restless legs syndrome in
the study, or 72 percent. The child's mother was three times more
likely to be the parent affected with restless legs syndrome.

"There seems to be a strong genetic component in restless legs
syndrome," says Dr. Kotagal. "Very often when taking the medical
history with the child, the parents say they have a similar
condition."

An additional characteristic seen in 25 percent of the patients was
inattentiveness.

The researchers note that the symptoms of restless legs occur most
often in the evening or around bedtime. Symptoms include discomfort or
needing to move the legs, which is alleviated by moving around.

"Children very often describe it as 'creepy crawlies,' as 'ouchies' or
'owies,'" says Dr. Kotagal. "It feels like bugs crawling on the legs.
One child described it as feeling like he was walking though snow.
There is also an uncontrollable urge to move the legs."

Dr. Kotagal believes that it is important to recognize and treat this
condition, as it hampers a child's lifestyle. "If affects the quality
of life," he says. "They wake up frequently in the night. They wake up
tired. They may also be inattentive during the day." The long-term
outcome of childhood restless legs syndrome is not known, according to
Dr. Kotagal, but it is treatable using medications that increase the
levels of dopamine in the central nervous system. Dr. Kotagal notes
that there is evidence that iron seems to be very important to the
synthesis of dopamine in the body. He says that there is not yet
sufficient evidence, however, that treatment with iron helps relieve
restless legs syndrome in children.

Dr. Kotagal indicates that there may be connections between restless
legs syndrome and attention deficit hyperactivity disorder. The
treatments for both conditions address somewhat the same chemical
imbalance, he notes.

"When we look at kids who have decreased attention span, over
one-third of them will have sleep apnea or restless legs syndrome," he
says. "We can say that it goes to further affirm the fact that
inattentiveness is multifactorial -- due to depression, anxiety,
stressors in the child's life, obstruction of breathing passageways,
sleep apnea or restless legs. We need to look at all of these
possibilities."

###



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