The easiest would be for the server admin of the MySQL box to allow access by the external web server, so that the web server can have a JDBC connector pointing directly at the source data. Then the JDBC connector could be used either to run the website directly or to feed a scheduled data migration process, like writing data to whatever DB is more local to the web server. I have had some success in the past connecting directly to Oracle data in New York from web servers in Cincinnati in real-time, once all the proper holes are opened in the various firewalls along the way.
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