Yes, vPC is compatible with ISSU and both os will work together while upgrading 
both boxes.

But upgrading from 4.2 to 5.x is disruptive 

Sent from my mobile

On Jan 27, 2011, at 6:19 AM, Manu Chao <[email protected]> wrote:

> I need to upgrade (ISSU) multiples N7K Dual Supervisor running vPC domains
> from NX-OS 4.2(6) to 5.1(1a).
> 
> Planned to upgrade first vPC operationnal Secondary chassis then Primary.
> 
> I have 2 questions:
> - Do you know if vPC is compatible with ISSU?
> - Does vPC work between NX-OS 4.2 and 5.1?
> 
> Thanks for your input
> Manu
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