On Jan 27, 2011, at 7:32 AM, <[email protected]<mailto:[email protected]>> 
wrote:

Yes, vPC is compatible with ISSU and both os will work together while upgrading 
both boxes.

But upgrading from 4.2 to 5.x is disruptive


+1

I'm sure the release notes say it, but the 4.x to 5.x major requires a full 
reload.  I spent a lot of time tracking down a BPDU rate limiting issue only to 
find the customer had ISSU'd from 4 to 5 and did not reload.
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