Thanks, Leanne. I'm supposed to be studying for a psychology exam tomorrow and have just enough time for "light" argument, but not "serious" debate, LOL.
All the best, Susan Cochran ----- Original Message ----- From: "Leanne Bertani" <[EMAIL PROTECTED]> To: <[EMAIL PROTECTED]> Sent: Tuesday, January 29, 2002 8:24 AM Subject: [CKCS-L] Dalmatians: homozygosity for a defective recessive gene > Some background information for the rest of us: > > > > Vet Clin North Am Small Anim Pract 1986 Jan;16(1):127-31 > Genetic predisposition to purine uroliths in Dalmatian dogs. > Schaible RH. > Homozygosity for a defective recessive gene results in all Dalmatians having > elevated concentrations of urine uric acid and predisposes them to formation > of purine uroliths. Why some animals form uroliths and others do not is not > known. > --------- > > The Dalmatian Club of America > FIFTEEN YEARS' DATA OF ALMOST > 3,000 DALMATIAN URINARY STONES > by Carroll H. Weiss > Study Group on Urinary Stones Research Committee Dalmatian Club of America > > Breeders inevitably ask, "If all Dalmatians are born with the defect, how do > we know which ones will shift from potential stone-formers to overt ones?" > The answer is no one knows nor is any kind of data gathering even possible > which could lead to plausible suggestions. There simply are overwhelmingly > too many factors influencing overt stone-forming to be surveyed in order to > come to any sort of statistically significant trends from which to draw even > preliminary answers to the question. Yes, it is known that diet and perhaps > the quality of local water purification can be two influences to push the > potential Dal into overt stone-forming but lurking in the background and > complicating any appraisal of a meaningful database of Dalmatians are many > other contributing factors, such as: > > how often each Dal is permitted to void, > how "normally" concentrated its urine is, > in the case of show entries, how often it leaves its home environment and to > where, > how accurate was the identification of abnormal crystals and stones > (reported to be 65 percent in error according to a published veterinarian > survey of U.S. assay methods). > > Breeders and fanciers now are reluctantly aware that every one of our > beloved breed is born with the potential of urate stone-forming because of > breed-specific defects of urine production in Dalmatian livers and kidneys. > I join with them in unhappily accepting this deplorable fact which has been > known and taught to veterinarians for 81 years. > I know some breeders claim "I have never had a stone-former in my line." I > sincerely and fervently wish this were so but what they really should be > saying is "I have never produced an overt stone-former" - or - "I have never > produced a Dalmatian who has shown abnormal urate crystals." Until every > puppy of every litter tests with no abnormal urinary crystals, until those > puppies grow up to become adults and, regardless wherever they live and > whatever they're fed and whatever they drink, continue to test without > abnormal urinary crystals, an unequivocal statement "I have never produced a > stone-former" is open to question. > > ========================================================= > "Magic Commands": > to stop receiving mail for awhile, click here and send the email: > mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20NOMAIL > to start it up gain click here: > mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20MAIL > > E-mail [EMAIL PROTECTED] for assistance. > Search the Archives... http://apple.ease.lsoft.com/archives/ckcs-l.html > > All e-mail sent through CKCS-L is Copyright 2002 by its original author. ========================================================= "Magic Commands": to stop receiving mail for awhile, click here and send the email: mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20NOMAIL to start it up gain click here: mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20MAIL E-mail [EMAIL PROTECTED] for assistance. Search the Archives... http://apple.ease.lsoft.com/archives/ckcs-l.html All e-mail sent through CKCS-L is Copyright 2002 by its original author.
