I've worked around this sort of thing in the past by wrapping the
initialization in a closure. My macros:

(defmacro once-fn "Define a function that should only be called once.
Releases local storage earlier"
  [args & body]
  `(^{:once true} fn* ~args ~...@body))

(defmacro top-level-run "work around a memory leak in the repl"
  [& body]
  `((once-fn []
      ~...@body)))

You'll find that:

(def out_of_mem (top-level-run (reduce + 0 (range 500000000))))

does not run out of memory.

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