--- In [EMAIL PROTECTED], "knottsm156" <[EMAIL PROTECTED]> wrote:
> Mark:
> 
> For me CML is the second kind of cancer I have had to deal with.  I 
> had a spinal cord tumor removed 18 years ago.  Fortunately it has 
not 
> recurred but I believe that the radiation therapy that I had is 
what 
> caused my CML.  So I have had 2 totally unrelated cancers.  
> 
> My neurologist told me that at St. Judes Children's Hospital they 
are 
> seeing secondary cancers in children already treated.  
> 
> I have always been diligent about getting a mammogram and annual 
> physical because my grandmother died from breast cancer.
> 
> Mary K
> 

Thanks Mary (and everyone else who responded) for sharing your 
history with recurring cancers.  Your post brings up an interesting 
point in this discussion which is that cancer treatment alone can 
raise the risk of recurring cancers. In addition to radiation, most 
chemotherapy treatments are known to be carcinogens.

When I was dx'd in April with a 332,000 WBC my doctor ramped up doses 
of hydrea to a whopping 10 pills a day (5g) to lower my WBC before 
starting Gleevec (to lower the risk of tumor lysis).  At any rate, I 
was amazed and somewhat amused to find out that even a relatively 
mild drug like Hydrea raises the risk of cancer because it deprives 
the body of adenine nucleotides. At first it struck me as somewhat 
funny when I thought to myself, "okay if I don't die from cancer now 
this medication is bound to make it so".  Later when I read more 
about the way hydrea works and I had mental images of all these 
chromosomes getting mangled during mitosis because of a lack of 
adenine, I didn't think it was quite as amusing..

My guess is that radiation and chemo drugs are an additional factor 
in our increased risk of getting other cancers.  It could be that 
this factor alone accounts for the seemingly high level of recurring 
cancers amongst cancer survivors.  But my guess (and again this is 
only a guess) is that there is more to it than the effects of 
treatment (radiation and chemo).  If anyone has seen any statistical 
studies on this please forward it to me.  

Thanks,
Mark Petersen
San Diego, CA
dx'd 4/27/04 w/ 20/20 (100% ph+)
400mg Gleevec 



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