Hey Cheryl, Thanks for the good stream of ASH reports
> Date: Sat, 04 Dec 2004 15:41:51 -0000 > From: "cher111376" <[EMAIL PROTECTED]> > Subject: Novel Agents in Leukemia - Part I - @ ASH > > Dr. H. summarized the various molecular methods of monitoring CML, > ending on the point that Quantitative PCR is the best (we haven't > heard this enough have we?). From here he re-stated what we had > heard earlier in the day that at dx you have 10^12 leukemia cells, at > CCR you have 10^10 I've heard this assertion before, but I don't believe it's not true. Let's stay you start out with a WBC of, say, 200,000, and that you are "100%" Philly positive by conventional cyto. At that point it's estimated that you have 10E12 (I've more often heard 10E13, but never mind, the point I'm making will be the same) Phillies in your body. If you respond well to IM and reduce your ANC to 2000, you're already lopped off two logs, down to 10E10; Let's say further that at diagnosis your ratio of Phillies to normal cells is 100/1 (obviously you're not really 100% Philly positive; it just looks it to the relatively insensitive conventional cyto test). When you reach CCR by conventional cyto, let's say that the ratio is now the opposite, 1 Philly to 100 normals. If the ANC is still 2000, you've thus dropped another 2 logs, (4 logs total) to 10E8 Phillies, not the 10E10 that's asserted here. And if you reach CCR by FISH, you're more likely to have reduced your Phillies by 5 logs total. Reaching CCR demonstrably decreases the qPCR by only a couple of logs, but there's an exponentialy, not a linear relationship between qPCR and leukemic load, as I've previously reported, and confirmed by the head of the laboratory at OHSU. So is my reasoning right here, or am I missing something? Any mathematicians out there who could help me out? Or perhaps it's a physiological matter, having to do with the quantity of Phillies hanging out in the peripheral blood vs the bone marrow at various stages of remission. Anyway, unless any of you has the answer, I think I'll email Dr. Druker about this once he gets back from ASH and see whether or not he agrees with Dr. H's assertion, and if so, how so. Cheers, Richard R ------------------------ Yahoo! Groups Sponsor --------------------~--> $4.98 domain names from Yahoo!. Register anything. http://us.click.yahoo.com/Q7_YsB/neXJAA/yQLSAA/8zSolB/TM --------------------------------------------------------------------~-> New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [EMAIL PROTECTED] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links <*> To visit your group on the web, go to: http://groups.yahoo.com/group/CML/ <*> To unsubscribe from this group, send an email to: [EMAIL PROTECTED] <*> Your use of Yahoo! Groups is subject to: http://docs.yahoo.com/info/terms/
